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Prof. Chris P Ponting BA MSc DPhil
Research Areas
Medical Sciences Division Themes
- Genetics and Genomics
- Bioinformatics and Statistics
- Neuroscience
Group Members
- Dr Leo Goodstadt, Postdoctoral Researcher
- Dr Caleb Webber, Postdoctoral Researcher
- Dr Andreas Heger, Postdoctoral Researcher
- Dr Martin Goodson, Postdoctoral Researcher
- Dr Lesheng Kong, Postdoctoral Researcher
- Stephen Meader, Graduate Student
- Robert Young, Graduate Student
- Dr Man-Suen Chan, Systems Administrator
- Dr Ana Marques, Portuguese National Fellow
- Dr Luis Sanchez-Pulido, EMBO Long Term Fellow
- T. Grant Belgard, NIH-Marshall Graduate Student
- Dr Christoffer Nellaker, Research Fellow
- Hannah Boulding, Graduate Student
Recent Publications
- Church Deanna M, Goodstadt Leo, Hillier Ladeana W, Zody Michael C, Goldstein Steve, She Xinwe, Bult Carol J, Agarwala Richa, Cherry Joshua L, DiCuccio Michael, Hlavina Wratko, Kapustin Yuri, Meric Peter, Maglott Donna, Birtle Zoe, Marques Ana C, Graves Tina, Zhou Shiguo, Teague Brian, Potamousis Konstantinos, Churas Christopher, Place Michael, Herschleb Jill, Runnheim Ron, Forrest Daniel, Amos-Landgraf James, Schwartz David C, Cheng Ze, Lindblad-Toh Kerstin, Eichler Evan E, and Ponting Chris P (2009) Lineage-specific biology revealed by a finished genome assembly of the mouse. PLoS Biol, 7(5):e1000112.
- Ponjavic Jasmina, Oliver Peter L, Lunter Gerton, and Ponting Chris P (2009) Genomic and transcriptional co-localization of protein-coding and long non-coding RNA pairs in the developing brain. PLoS Genet, 5(8):e1000617.
- Ponting Chris P, Oliver Peter L, and Reik Wolf (2009) Evolution and functions of long noncoding RNAs. Cell, 136(4):629-41.
- Webber Caleb, Hehir-Kwa Jayne Y, Nguyen Duc-Quang, de Vries Bert BA, Veltman Joris A, and Ponting Chris P (2009) Forging links between human mental retardation-associated CNVs and mouse gene knockout models. PLoS Genet, 5(6):e1000531.
- Nguyen Duc-Quang, Webber Caleb, Hehir-Kwa Jayne, Pfundt Rolph, Veltman Joris, and Ponting Chris P (2008) Reduced purifying selection prevails over positive selection in human copy number variant evolution. Genome Res, 18(11):1711-23.
| chris.ponting@dpag.ox.ac.uk | |
| Tel | 01865 285855 |
| Fax | 01865 285862 |
| PA | Unit Secretary: Sarah Atkinson |
| Email (PA) | sarah.atkinson@dpag.ox.ac.uk |
| Tel (PA) | 01865 285867 |
| Fax (PA) | 01865 285862 |
| Contact address | MRC Functional Genomics Unit Department of Physiology Anatomy & Genetics Le Gros Clark Building University of Oxford South Parks Road Oxford OX1 3QX United Kingdom |
| Department |
Department of Physiology, Anatomy and Genetics
Oxford Centre for Gene Function |
My group is studying the evolution of genes and genomes using comparative genomics methods. The group contributed to the publicly-funded Human Genome Project described in Nature (2001) and in (2004) (PubMed), and performed much of the protein comparisons for mouse, (PubMed), rat (PubMed), chicken (PubMed), dog (PubMed) and marsupial (PubMed) Genome Projects, also published in Nature. Our work has the important benefit of reducing the number of animals used in experiments.
Our work occurs at the intersection between comparative genomics, evolutionary analyses and molecular structure-function predictions. We take new sequence data from mammalian and model organism genomes and use these to illuminate how evolution has shaped our genomes and genes, and how we are different from one another. We also analyse parasite and pathogen genomes in order to address issues of communicable diseases. Our primary aim is to understand the contribution each DNA base in the human genome makes to the functionality of our species.
Our research is multi-faceted and multi-disciplinary. We seek to understand the roles of proteins, non-coding genes and other functional elements in the evolution, development and disease-susceptibility of humans. We study how our DNA is conserved, with respect to other species, or how it is different among members of our own species. Finally, our computational findings are used to help inform experiments that elucidate function
The group is also interested in the prediction of structure, function and evolution of genes of interest to the biomedical community in general, and to the groups of the MRC Functional Genomics Unit in particular. We contributed, for example, to the understanding of the function and evolution of genes implicated in asthma, familial Alzheimer's disease, breast cancer, Aicardi-Goutiere's syndrome (PubMed), obesity (PubMed) and muscular dystrophies. The group is a major contributor to the Oxford Parkinson’s Disease Centre (http://opdc.medsci.ox.ac.uk/) which was recently awarded £5m over 5 years by the Parkinson’s Disease Society to determine the earliest pathological pathways in Parkinson's disease.
For further information, visit Ponting Group Web Resources.
For an up-to-date list of PubMed publications, please click here
Main Collaborators
Richard Copley, Richard Mott and Jonathan Flint, Wellcome Trust Centre for Human Genetics, Oxford.
Broad Institute (Kerstin Lindblad-Toh)
Baylor College of Medicine HGSC (George Weinstock)
Washington Univ. St Louis GSC (LaDeana Hillier)
Ewan Birney (EBI)
Joris Veltman (University Medical Center Nijmegen)
Past Group Members
Richard Emes
Steve Rice
Scott Beatson
Pat Clissold
Nick Dickens
Michael Elkaim
Eitan Winter
Jose Duarte
Zoe Birtle
Jasmina Ponjavic
Duc-Quang Nguyen
Gerton Lunter
Tania Oh